Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases | Zendy

Jenny Calvén | Zendy; Yulyana Yudina | Zendy; Oskar Hällgren | Zendy; Gunilla WestergrenThorsson | Zendy; Donna E. Davies | Zendy; Angelica Brandelius | Zendy; Lena Uller | Zendy

Open Access

Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases

Author(s) -

Jenny Calvén,

Yulyana Yudina,

Oskar Hällgren,

Gunilla WestergrenThorsson,

Donna E. Davies,

Angelica Brandelius,

Lena Uller

Publication year - 2011

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000329131

Subject(s) - thymic stromal lymphopoietin , tlr3 , cytokine , biology , endosome , inflammation , immunology , microbiology and biotechnology , toll like receptor , innate immune system , immune system , intracellular

Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD) exacerbations exhibit TH(2)-like inflammation. We hypothesized that RV-infected bronchial epithelial cells (BEC) overproduce TH(2)-switching hub cytokine, thymic stromal lymphopoietin (TSLP) in COPD.

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