I-CLIP: Improved Stratification of Advanced Hepatocellular Carcinoma Patients by Integrating Plasma IGF-1 into CLIP Score | Zendy

Ahmed O. Kaseb | Zendy; James L. Abbruzzese | Zendy; JeanNicolas Vauthey | Zendy; Thomas A. Aloia | Zendy; Eddie K. Abdalla | Zendy; Manal M. Hassan | Zendy; E. Lin | Zendy; Lianchun Xiao | Zendy; Adel S. ElDeeb | Zendy; Asif Rashid | Zendy; Jeffrey S. Morris | Zendy

Open Access

I-CLIP: Improved Stratification of Advanced Hepatocellular Carcinoma Patients by Integrating Plasma IGF-1 into CLIP Score

Author(s) -

Ahmed O. Kaseb,

James L. Abbruzzese,

JeanNicolas Vauthey,

Thomas A. Aloia,

Eddie K. Abdalla,

Manal M. Hassan,

E. Lin,

Lianchun Xiao,

Adel S. ElDeeb,

Asif Rashid,

Jeffrey S. Morris

Publication year - 2011

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000329040

Subject(s) - hepatocellular carcinoma , medicine , proportional hazards model , concordance , oncology , liver cancer , gastroenterology , survival analysis , risk stratification , overall survival , recursive partitioning , multivariate analysis

Improving the prognostic stratification of unresectable hepatocellular carcinoma (HCC) patients is critically needed. Since patients' survival is closely linked to the severity of the underlying liver disease, and insulin-like growth factor-1 (IGF-1) is produced predominantly in the liver, we hypothesized that IGF-1 may correlate with patients' survival and hence improve the prognostic ability of the Cancer of the Liver Italian Program (CLIP) score.

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