Potential Role of Serine Proteases in Modulating Renal Sodium Transport in vivo | Zendy

Grégory Jacquillet | Zendy; Isabelle Rubera | Zendy; Robert J. Unwin | Zendy

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Potential Role of Serine Proteases in Modulating Renal Sodium Transport in vivo

Author(s) -

Grégory Jacquillet,

Isabelle Rubera,

Robert J. Unwin

Publication year - 2011

Publication title -

nephron physiology

Language(s) - English

Resource type - Journals

ISSN - 1660-2137

DOI - 10.1159/000328926

Subject(s) - reabsorption , proteases , nephron , sodium , homeostasis , kidney , chemistry , serine , renal sodium reabsorption , medicine , renal function , endocrinology , in vivo , renal physiology , biochemistry , biology , enzyme , microbiology and biotechnology , organic chemistry

The maintenance of sodium (Na+) homeostasis is an essential function of the kidney. It is achieved by a variety of transport processes localized all along the highly specialised segments of the nephron. Impairment of these transport mechanisms, and thereby Na+ handling, is associated with disturbed Na+ and water balance, leading to hypertension and oedema. This review focuses on the novel regulation of sodium reabsorption by serine proteases acting along the entire nephron.

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