Open AccessColonic Inflammation Increases the Contribution of Muscarinic M<sub>2</sub> Receptors to Carbachol-Induced Contraction of the Rat Colon
Author(s) -
Dina M. Jragh,
Islam Ullah Khan,
Mabayoje A. Oriowo
Publication year - 2011
Publication title -
medical principles and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 45
eISSN - 1423-0151
pISSN - 1011-7571
DOI - 10.1159/000328419
Subject(s) - carbachol , muscarinic acetylcholine receptor , methoctramine , pirenzepine , medicine , endocrinology , muscarinic acetylcholine receptor m3 , receptor , contraction (grammar)
Carbachol-induced contraction of the rat colon is impaired in rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. The main objective of this study was to examine the effect of colitis on the expression and function of muscarinic (M) receptor subtypes in the rat colon.
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