Natural Killer Cells in Psoriasis | Zendy

AnneMarie Tobin | Zendy; Lydia Lynch | Zendy; Brian Kirby | Zendy; Cliona OʼFarrelly | Zendy

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Natural Killer Cells in Psoriasis

Author(s) -

AnneMarie Tobin,

Lydia Lynch,

Brian Kirby,

Cliona OʼFarrelly

Publication year - 2011

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000328011

Subject(s) - psoriasis , innate immune system , immunology , immune system , natural killer cell , cytokine , biology , tumor necrosis factor alpha , pathogenesis , dominance (genetics) , cytotoxic t cell , in vitro , gene , genetics

Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

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