Effect of Cystamine on Blood Pressure and Vascular Characteristics in Spontaneously Hypertensive Rats | Zendy

Morten Engholm | Zendy; Ashkan Eftekhari | Zendy; Grażyna Chwatko | Zendy; Edward Bald | Zendy; Michael J. Mulvany | Zendy

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Effect of Cystamine on Blood Pressure and Vascular Characteristics in Spontaneously Hypertensive Rats

Author(s) -

Morten Engholm,

Ashkan Eftekhari,

Grażyna Chwatko,

Edward Bald,

Michael J. Mulvany

Publication year - 2011

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000327773

Subject(s) - cystamine , myograph , in vivo , mesenteric arteries , medicine , chemistry , endocrinology , blood pressure , blood vessel , artery , hemodynamics , biochemistry , biology , microbiology and biotechnology

Tissue transglutaminase (t-TG) has been implicated in small artery remodelling. The aim of this study was to determine if cystamine, an inhibitor of t-TG, could reduce blood pressure in spontaneously hypertensive rats (SHR) and if so to what extent this is mediated through small arteries.

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