In Search of a Vaccine for Mouse Allergy: Significant Reduction of Mus m 1 Allergenicity by Structure-Guided Single-Point Mutations | Zendy

Elena Ferrari | Zendy; Daniela Breda | Zendy; Renato Longhi | Zendy; Luca Vangelista | Zendy; Clóvis R. Nakaie | Zendy; Lisa Elviri | Zendy; Emanuela Casali | Zendy; Thelma A. Pertinhez | Zendy; Alberto Spisni | Zendy; Samuele E. Burastero | Zendy

Open Access

In Search of a Vaccine for Mouse Allergy: Significant Reduction of Mus m 1 Allergenicity by Structure-Guided Single-Point Mutations

Author(s) -

Elena Ferrari,

Daniela Breda,

Renato Longhi,

Luca Vangelista,

Clóvis R. Nakaie,

Lisa Elviri,

Emanuela Casali,

Thelma A. Pertinhez,

Alberto Spisni,

Samuele E. Burastero

Publication year - 2011

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000327551

Subject(s) - immunogenicity , epitope , microbiology and biotechnology , allergen , point mutation , recombinant dna , in silico , biology , chemistry , in vitro , antigen , immunology , mutant , allergy , biochemistry , gene

Mouse urinary proteins are relevant allergens from mice urine. We used the recombinant protein Mus m 1 as an allergen model to identify if, by altering Mus m 1 architecture via single-point mutations, we could effectively modify its allergenicity.

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