Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series | Zendy

Norbert Gleicher | Zendy; David H. Barad | Zendy

Open Access

Gestational Dermatosis Shortly after Implantation Associated with Parental Class II HLA Compatibility and Maternal Immune Activation: Preliminary Report of a Prospective Case Series

Author(s) -

Norbert Gleicher,

David H. Barad

Publication year - 2011

Publication title -

dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.224

H-Index - 92

eISSN - 1421-9832

pISSN - 1018-8665

DOI - 10.1159/000327377

Subject(s) - medicine , human leukocyte antigen , immune system , immunology , prospective cohort study , pregnancy , biology , antigen , genetics

Pregnancy represents a semi-allograft, subject to similar immune responses as allogeneic organ transplants. Tolerance of pregnancy appears best with maximal class II HLA heterogeneity between mother and father, while compatibilities are associated with increased pregnancy loss and maternal autoimmunity. Tolerance abnormalities often involve skin reactions. Abnormalities in tolerance of the fetal graft may do the same.

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