Genetic Association Studies: Discovery of the Genetic Basis of Renal Disease | Zendy

Marion Verduijn | Zendy; Kitty J. Jager | Zendy; Carmine Zoccali | Zendy; Friedo W. Dekker | Zendy

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Genetic Association Studies: Discovery of the Genetic Basis of Renal Disease

Author(s) -

Marion Verduijn,

Kitty J. Jager,

Carmine Zoccali,

Friedo W. Dekker

Publication year - 2011

Publication title -

nephron clinical practice

Language(s) - English

Resource type - Journals

ISSN - 1660-2110

DOI - 10.1159/000326685

Subject(s) - genetic association , genome wide association study , disease , medicine , candidate gene , etiology , bioinformatics , genetics , gene , biology , genotype , pathology , single nucleotide polymorphism

Genetic association studies are a means to investigate the causal role of genes in diseases in order to unravel pathways involved in the etiology of disease. There are two types of genetic association studies: hypothesis-driven studies, i.e. candidate gene studies, targeting genes with a known or presumed role in pathways or diseases of interest, and non-hypothesis-driven studies, i.e. genome-wide association studies, aiming for the discovery of new genetic associations. This educational article is an introduction to genetic association studies for nephrologists and researchers in the domain of kidney disease.

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