Effect of a Phosphodiesterase 5 Inhibitor on Pulmonary and Cerebral Arteries of Newborn Piglets with Chronic Hypoxia-Induced Pulmonary Hypertension | Zendy

Candice D. Fike | Zendy; Mark R. Kaplowitz | Zendy; Yongmei Zhang | Zendy; Mark W. Dantuma | Zendy; Jane A. Madden | Zendy

Open Access

Effect of a Phosphodiesterase 5 Inhibitor on Pulmonary and Cerebral Arteries of Newborn Piglets with Chronic Hypoxia-Induced Pulmonary Hypertension

Author(s) -

Candice D. Fike,

Mark R. Kaplowitz,

Yongmei Zhang,

Mark W. Dantuma,

Jane A. Madden

Publication year - 2011

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000326270

Subject(s) - zaprinast , medicine , pulmonary hypertension , hypoxia (environmental) , cerebral arteries , cerebral circulation , pulmonary artery , anesthesia , middle cerebral artery , cardiology , nitric oxide , ischemia , chemistry , organic chemistry , oxygen , guanylate cyclase

The use of phosphodiesterase 5 (PDE5) inhibitors to treat newborns with pulmonary hypertension is increasing. The effect of PDE5 inhibitors on the neonatal cerebral circulation remains unknown. The neonatal piglet model of chronic hypoxia-induced pulmonary hypertension allows the study of the effects of PDE5 inhibitors on both the pulmonary and cerebral circulations.

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