Tanshinone IIA Prevented Brain Iron Dyshomeostasis in Cerebral Ischemic Rats | Zendy

Lei Yang | Zendy; Bisi Zhang | Zendy; Li Yin | Zendy; Benzhi Cai | Zendy; Hongli Shan | Zendy; Li Zhang | Zendy; Yanjie Lu | Zendy; Zheng-gang Bi | Zendy

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Tanshinone IIA Prevented Brain Iron Dyshomeostasis in Cerebral Ischemic Rats

Author(s) -

Lei Yang,

Bisi Zhang,

Li Yin,

Benzhi Cai,

Hongli Shan,

Li Zhang,

Yanjie Lu,

Zheng-gang Bi

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000325202

Subject(s) - dmt1 , chemistry , pharmacology , western blot , ischemia , homeostasis , efflux , medicine , endocrinology , biochemistry , transporter , gene

Tanshinone IIA is a lipid-soluble compound extracted from Chinese herb Danshen which was commonly used in the treatment of cerebrovascular diseases. Brain iron homeostasis is very essential for normal physiological functions of neurons, and brain iron accumulation contributes to many neurological disorders. The present study was aimed to determine whether Tanshinone IIA protects against cerebral ischemic injury via maintaining brain iron homeostasis.

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