Cellular and Molecular Responses of the Basilar Terminus to Hemodynamics during Intracranial Aneurysm Initiation in a Rabbit Model | Zendy

John Kolega | Zendy; Ling Gao | Zendy; Max Mandelbaum | Zendy; J Mocco | Zendy; Adnan H. Siddiqui | Zendy; Sabareesh K. Natarajan | Zendy; Hui Meng | Zendy

Open Access

Cellular and Molecular Responses of the Basilar Terminus to Hemodynamics during Intracranial Aneurysm Initiation in a Rabbit Model

Author(s) -

John Kolega,

Ling Gao,

Max Mandelbaum,

J Mocco,

Adnan H. Siddiqui,

Sabareesh K. Natarajan,

Hui Meng

Publication year - 2011

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000324840

Subject(s) - hemodynamics , basilar artery , aneurysm , cardiology , medicine , surgery

Hemodynamics constitute a critical factor in the formation of intracranial aneurysms. However, little is known about how intracranial arteries respond to hemodynamic insult and how that response contributes to aneurysm formation. We examined early cellular responses at rabbit basilar termini exposed to hemodynamic insult that initiates aneurysmal remodeling.

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