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In Alzheimer's disease, neurodegenerative atrophy progresses from the entorhinal cortex (ERC) to the hippocampus (HP), limbic system and neocortex. The significance of very mild atrophy of the ERC and HP on MRI scans among elderly subjects is unknown.

Minimal Atrophy of the Entorhinal Cortex and Hippocampus: Progression of Cognitive Impairment