Abnormalities in the Enamel in Bmp2-Deficient Mice | Zendy

Junsheng Feng | Zendy; Guobin Yang | Zendy; Guohua Yuan | Zendy; Jelica GluhakHeinrich | Zendy; Wuchen Yang | Zendy; Lynn Wang | Zendy; Zhi Chen | Zendy; Jennifer S. McDaniel | Zendy; Kevin J. Donly | Zendy; Stephen E. Harris | Zendy; Mary MacDougall | Zendy; Shuo Chen | Zendy

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Abnormalities in the Enamel in Bmp2-Deficient Mice

Author(s) -

Junsheng Feng,

Guobin Yang,

Guohua Yuan,

Jelica GluhakHeinrich,

Wuchen Yang,

Lynn Wang,

Zhi Chen,

Jennifer S. McDaniel,

Kevin J. Donly,

Stephen E. Harris,

Mary MacDougall,

Shuo Chen

Publication year - 2011

Publication title -

cells tissues organs

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.662

H-Index - 82

ISSN - 1422-6405

DOI - 10.1159/000324644

Subject(s) - enamel paint , bone morphogenetic protein 2 , ameloblast , enamel organ , dentistry , pulp (tooth) , microbiology and biotechnology , chemistry , biology , medicine , in vitro , biochemistry

Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2(flox/flox) mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation.

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