Foreign Gene Transfer to Cardiomyocyte Using a Replication-Defective Recombinant Coxsackievirus B3 without Cytotoxicity | Zendy

ByungKwan Lim | Zendy; SooHyeon Yun | Zendy; Chae-Ok Gil | Zendy; EunSeon Ju | Zendy; Jin-Oh Choi | Zendy; DukKyung Kim | Zendy; EunSeok Jeon | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Foreign Gene Transfer to Cardiomyocyte Using a Replication-Defective Recombinant Coxsackievirus B3 without Cytotoxicity

Author(s) -

ByungKwan Lim,

SooHyeon Yun,

Chae-Ok Gil,

EunSeon Ju,

Jin-Oh Choi,

DukKyung Kim,

EunSeok Jeon

Publication year - 2011

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000324541

Subject(s) - luciferase , transfection , microbiology and biotechnology , biology , hek 293 cells , coxsackievirus , cytotoxicity , cell culture , plasmid , viral replication , genetic enhancement , virology , gene , virus , in vitro , enterovirus , biochemistry , genetics

Replication-competent coxsackievirus B3 (CVB3) has been used as a gene transfer vector for cultured cardiomyocytes and hearts in vivo. However, CVB3 induces cell lysis when it replicates in infected cells. In this study, we investigated whether a replication-defective rCVB3 vector could be generated and used as a noncytotoxic gene transfer vector for cardiomyocytes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research