Levels of Surfactant Proteins A and D and KL-6 Are Elevated in the Induced Sputum of Chronic Obstructive Pulmonary Disease Patients: A Sequential Sputum Analysis | Zendy

Nobuhisa Ishikawa | Zendy; Noboru Hattori | Zendy; Sonosuke Tanaka | Zendy; Yasushi Horimasu | Zendy; Yoshinori Haruta | Zendy; Akihito Yokoyama | Zendy; Nobuoki Kohno | Zendy; Vuokko L. Kinnula | Zendy

Open Access

Levels of Surfactant Proteins A and D and KL-6 Are Elevated in the Induced Sputum of Chronic Obstructive Pulmonary Disease Patients: A Sequential Sputum Analysis

Author(s) -

Nobuhisa Ishikawa,

Noboru Hattori,

Sonosuke Tanaka,

Yasushi Horimasu,

Yoshinori Haruta,

Akihito Yokoyama,

Nobuoki Kohno,

Vuokko L. Kinnula

Publication year - 2011

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000324539

Subject(s) - medicine , sputum , pulmonary disease , copd , respiratory disease , pulmonary surfactant , gastroenterology , pathology , lung , biochemistry , tuberculosis , chemistry

Recent clinical studies have suggested that serum surfactant protein (SP) A, SP-D and Krebs von den Lungen-6 (KL-6) are potential biomarkers for interstitial lung diseases. Serum levels of SP-A and SP-D have also been found to be elevated in chronic obstructive pulmonary disease (COPD), but their significance has not been evaluated or compared in induced sputum samples obtained directly from the airways.

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