Induction of Antibodies Binding to the Membrane Proximal External Region of gp36 of HIV-2 | Zendy

Rayk Behrendt | Zendy; Uwe Fiebig | Zendy; Reinhard Kurth | Zendy; Joachim Denner | Zendy

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Induction of Antibodies Binding to the Membrane Proximal External Region of gp36 of HIV-2

Author(s) -

Rayk Behrendt,

Uwe Fiebig,

Reinhard Kurth,

Joachim Denner

Publication year - 2011

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000324483

Subject(s) - gp41 , epitope , monoclonal antibody , antibody , ectodomain , virology , biology , recombinant dna , transmembrane protein , immunology , receptor , biochemistry , gene

The ability to induce neutralizing antibodies may be the most important feature of an antiretroviral vaccine, preventing infection of target cells and subsequent integration of the virus into the cellular genome where the virus may persist. Broadly neutralizing antibodies directed against conserved epitopes in the membrane proximal external region (MPER) of the transmembrane envelope (TM) protein gp41 of HIV-1 such as the monoclonal antibodies (mAb) 2F5 and mAb 4E10 have been found in infected individuals; however, all attempts to induce such antibodies failed. In individuals infected with HIV-2 such antibodies were not yet reported.

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