Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation | Zendy

Asha Eapen | Zendy; Amsaveni Ramachandran | Zendy; Jitesh Pratap | Zendy; Anne George | Zendy

Open Access

Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation

Author(s) -

Asha Eapen,

Amsaveni Ramachandran,

Jitesh Pratap,

Anne George

Publication year - 2011

Publication title -

cells tissues organs

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.662

H-Index - 82

ISSN - 1422-6405

DOI - 10.1159/000324258

Subject(s) - dmp1 , runx2 , mapk/erk pathway , microbiology and biotechnology , osteoblast , chemistry , protein kinase a , kinase , mitogen activated protein kinase kinase , mapk cascade , mitogen activated protein kinase , extracellular matrix , mitogen activated protein kinase 3 , signal transduction , biology , biochemistry , viral matrix protein , in vitro , gene

DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway.

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