Cyclosporin-A Induced Toxicity in Rat Renal Collecting Duct Cells: Interference with Enhanced Hypertonicity Induced Apoptosis | Zendy

Laura K. Schenk | Zendy; Markus M. Rinschen | Zendy; Jens Klokkers | Zendy; Sunil M. Kurian | Zendy; Ute Neugebauer | Zendy; Daniel R. Salomon | Zendy; Hermann Pavenstaedt | Zendy; Eberhard Schlatter | Zendy; Bayram Edemir | Zendy

Open Access

Cyclosporin-A Induced Toxicity in Rat Renal Collecting Duct Cells: Interference with Enhanced Hypertonicity Induced Apoptosis

Author(s) -

Laura K. Schenk,

Markus M. Rinschen,

Jens Klokkers,

Sunil M. Kurian,

Ute Neugebauer,

Daniel R. Salomon,

Hermann Pavenstaedt,

Eberhard Schlatter,

Bayram Edemir

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000323998

Subject(s) - apoptosis , cytotoxicity , toxicity , tonicity , programmed cell death , biology , nephrotoxicity , gene expression , receptor , microbiology and biotechnology , microarray analysis techniques , chemistry , kidney , endocrinology , in vitro , gene , biochemistry , organic chemistry

Rat renal inner medullary collecting duct (IMCD) cells are physiologically exposed to a wide range of ambient tonicity. To maintain their function upon changes in osmolality, IMCD cells induce expression of osmoprotective and antiapoptotic genes, mainly mediated by the transcription factor Tonicity Enhancer Binding Protein (TonEBP). Some drugs like Cyclosporin-A (CsA) are discussed to interfere with the activity of TonEBP and thereby mediate their nephrotoxic effects. The aim of our study was to further understand CsA toxicity during elevation of ambient osmolality.

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