N-n-butyl Haloperidol Iodide Protects Cardiac Microvascular Endothelial Cells From Hypoxia/Reoxygenation Injury by Down-Regulating Egr-1 Expression | Zendy

Yanqiong Zhou | Zendy; Yanmei Zhang | Zendy; Fenfei Gao | Zendy; Fuxiao Guo | Zendy; Jinzhi Wang | Zendy; Wenfeng Cai | Zendy; Yicun Chen | Zendy; Jinhong Zheng | Zendy; Ganggang Shi | Zendy

Open Access

<i>N</i>-n-butyl Haloperidol Iodide Protects Cardiac Microvascular Endothelial Cells From Hypoxia/Reoxygenation Injury by Down-Regulating Egr-1 Expression

Author(s) -

Yanqiong Zhou,

Yanmei Zhang,

Fenfei Gao,

Fuxiao Guo,

Jinzhi Wang,

Wenfeng Cai,

Yicun Chen,

Jinhong Zheng,

Ganggang Shi

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000323993

Subject(s) - lactate dehydrogenase , malondialdehyde , reperfusion injury , viability assay , western blot , superoxide dismutase , endothelial stem cell , chemistry , hypoxia (environmental) , endothelium , microbiology and biotechnology , pharmacology , andrology , biology , ischemia , medicine , oxidative stress , endocrinology , apoptosis , biochemistry , enzyme , in vitro , oxygen , organic chemistry , gene

Our previous studies have shown that N-n-butyl haloperidol iodide (F2) can antagonize myocardial ischemia/reperfusion (I/R) injury by down-regulating the early growth response (Egr)-1 expression, but the molecular mechanisms are not well understood. Because there is evidence implicating myocardial I/R injury is closely associated with endothelial dysfunction. The present study is to test the hypothesis that the protective effects of F2 on myocardial I/R injury is related closely with down-regulating Egr-1 expression on cardiac microvascular endothelial cells (CMECs).

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