Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes | Zendy

Anna Caretti | Zendy; Paola Bianciardi | Zendy; G Sala | Zendy; Carlo Terruzzi | Zendy; Franco Lucchina | Zendy; Michele Samaja | Zendy

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Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes

Author(s) -

Anna Caretti,

Paola Bianciardi,

G Sala,

Carlo Terruzzi,

Franco Lucchina,

Michele Samaja

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000323992

Subject(s) - ampk , creatine , poly adp ribose polymerase , creatine kinase , ribose , apoptosis , ischemia , medicine , endocrinology , protein kinase a , chemistry , biology , kinase , biochemistry , enzyme , polymerase

To alleviate ischemia-induced injury in the myocardium, a tissue that depends critically on energy-yielding processes, creatine may be used to enhance energy metabolism, whereas D-ribose may provide building blocks for ATP synthesis. We test the hypothesis that simultaneous supplementation of creatine+D-ribose protects non-irreversibly injured ischemic cardiomyocytes by reducing apoptosis.

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