Lack of Transient Receptor Potential Vanilloid-1 Enhances Th2-Biased Immune Response of the Airways in Mice Receiving Intranasal, but Not Intraperitoneal, Sensitization | Zendy

Tetsuya Mori | Zendy; Katsuyo Saito | Zendy; Yasushi Ohki | Zendy; Hirokazu Arakawa | Zendy; Makoto Tominaga | Zendy; Kenichi Tokuyama | Zendy

Open Access

Lack of Transient Receptor Potential Vanilloid-1 Enhances Th2-Biased Immune Response of the Airways in Mice Receiving Intranasal, but Not Intraperitoneal, Sensitization

Author(s) -

Tetsuya Mori,

Katsuyo Saito,

Yasushi Ohki,

Hirokazu Arakawa,

Makoto Tominaga,

Kenichi Tokuyama

Publication year - 2011

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000323889

Subject(s) - sensitization , immunology , nasal administration , transient receptor potential channel , immune system , medicine , receptor , intraperitoneal injection , pharmacology

Transient receptor potential vanilloid-1 (TRPV1) may modulate allergic airway inflammation because it is expressed not only on the nerve endings but also on several cells of the immune system. We wanted to know the characteristics of airway and systemic responses against sensitization and challenge with allergens in TRPV1 receptor gene knockout mice (TRPV1(-/-)).

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