Decreased RECK and Increased EMMPRIN Expression in Urothelial Carcinoma of the Bladder Are Associated with Tumor Aggressiveness | Zendy

Daniel Wittschieber | Zendy; Albrecht Stenzinger | Zendy; Frederick Klauschen | Zendy; Carsten Stephan | Zendy; Klaus Jung | Zendy; Andreas Erbersdobler | Zendy; Anja Rabien | Zendy

Open Access

Decreased RECK and Increased EMMPRIN Expression in Urothelial Carcinoma of the Bladder Are Associated with Tumor Aggressiveness

Author(s) -

Daniel Wittschieber,

Albrecht Stenzinger,

Frederick Klauschen,

Carsten Stephan,

Klaus Jung,

Andreas Erbersdobler,

Anja Rabien

Publication year - 2011

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000323563

Subject(s) - immunohistochemistry , downregulation and upregulation , medicine , matrix metalloproteinase , bladder cancer , stromal cell , stage (stratigraphy) , cystectomy , carcinoma , cancer research , urothelial carcinoma , pathology , cancer , biology , gene , paleontology , biochemistry

Urothelial bladder carcinomas show a divergent biological behavior, which significantly complicates risk stratification and clinical management. The MMP repressor RECK and the MMP activator EMMPRIN regulate the invasive potential by metalloproteinase-induced stromal degradation. Data on RECK in urothelial bladder cancer are lacking and information on EMMPRIN is sparse. This study aims to investigate the expression of RECK and EMMPRIN in urothelial carcinoma of the bladder and to correlate these findings with clinicopathological parameters.

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