The Progressive Ankylosis Protein Regulates Cementum Apposition and Extracellular Matrix Composition | Zendy

Brian L. Foster | Zendy; Kanako J. Nagatomo | Zendy; Shatha Bamashmous | Zendy; Kevin A. Tompkins | Zendy; Hanson Fong | Zendy; D. Dunn | Zendy; Emily Y. Chu | Zendy; Catherine Guenther | Zendy; David M. Kingsley | Zendy; R. Bruce Rutherford | Zendy; Martha J. Somerman | Zendy

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The Progressive Ankylosis Protein Regulates Cementum Apposition and Extracellular Matrix Composition

Author(s) -

Brian L. Foster,

Kanako J. Nagatomo,

Shatha Bamashmous,

Kevin A. Tompkins,

Hanson Fong,

D. Dunn,

Emily Y. Chu,

Catherine Guenther,

David M. Kingsley,

R. Bruce Rutherford,

Martha J. Somerman

Publication year - 2011

Publication title -

cells tissues organs

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.662

H-Index - 82

ISSN - 1422-6405

DOI - 10.1159/000323457

Subject(s) - cementoblast , cementum , cementogenesis , dental cementum , chemistry , periodontal fiber , microbiology and biotechnology , extracellular matrix , anatomy , dentin , biology , biochemistry , pathology , dentistry , medicine

Tooth root cementum is sensitive to modulation of inorganic pyrophosphate (PP(i)), an inhibitor of hydroxyapatite precipitation. Factors increasing PP(i) include progressive ankylosis protein (ANK) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) while tissue nonspecific alkaline phosphatase hydrolyzes PP(i). Studies here aimed to define the role of ANK in root and cementum by analyzing tooth development in Ank knock-out (KO) mice versus wild type.

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