An Exploratory Study on the CHRNA3-CHRNA5-CHRNB4 Cluster, Smoking, and Parkinson’s Disease | Zendy

Jianjun Gao | Zendy; Hong Xu | Zendy; Clarice R. Weinberg | Zendy; Xuemei Huang | Zendy; Yikyung Park | Zendy; Albert R. Hollenbeck | Zendy; Aaron Blair | Zendy; Arthur Schatzkin | Zendy; Lauranell H. Burch | Zendy; Honglei Chen | Zendy

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An Exploratory Study on the <i>CHRNA3-CHRNA5-CHRNB4 </i>Cluster, Smoking, and Parkinson’s Disease

Author(s) -

Jianjun Gao,

Hong Xu,

Clarice R. Weinberg,

Xuemei Huang,

Yikyung Park,

Albert R. Hollenbeck,

Aaron Blair,

Arthur Schatzkin,

Lauranell H. Burch,

Honglei Chen

Publication year - 2011

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000323190

Subject(s) - genome wide association study , single nucleotide polymorphism , linkage disequilibrium , odds ratio , genetic association , medicine , population , logistic regression , oncology , genetics , genotype , biology , environmental health , gene

Smokers have a lower risk of Parkinson's disease (PD). Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Investigations into these SNPs may help explain the nature and mechanisms of the smoking-PD relationship.

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