Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms | Zendy

Adam WhaleyConnell | Zendy; Lakshmi Pulakat | Zendy; Vincent G. DeMarco | Zendy; Melvin R. Hayden | Zendy; Javad Habibi | Zendy; Erik J. Henriksen | Zendy; James R. Sowers | Zendy

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Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms

Author(s) -

Adam WhaleyConnell,

Lakshmi Pulakat,

Vincent G. DeMarco,

Melvin R. Hayden,

Javad Habibi,

Erik J. Henriksen,

James R. Sowers

Publication year - 2011

Publication title -

cardiorenal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.661

H-Index - 21

eISSN - 1664-3828

pISSN - 1664-5502

DOI - 10.1159/000322827

Subject(s) - overnutrition , medicine , cardiorenal syndrome , hyperinsulinemia , obesity , kidney disease , insulin resistance , diabetes mellitus , endocrinology

Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.

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