Angiopoietin-Like 4 (ANGPTL4) Gene Polymorphisms and Risk of Brain Arteriovenous Malformations | Zendy

Bahar Mikhak | Zendy; Shantel Weinsheimer | Zendy; Ludmila Pawlikowska | Zendy; Annie Poon | Zendy; PuiYan Kwok | Zendy; Michael T. Lawton | Zendy; Yongmei Chen | Zendy; Jonathan G. Zaroff | Zendy; Stephen Sidney | Zendy; Charles E. McCulloch | Zendy; William L. Young | Zendy; Helen Kim | Zendy

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Angiopoietin-Like 4 <i>(ANGPTL4)</i> Gene Polymorphisms and Risk of Brain Arteriovenous Malformations

Author(s) -

Bahar Mikhak,

Shantel Weinsheimer,

Ludmila Pawlikowska,

Annie Poon,

PuiYan Kwok,

Michael T. Lawton,

Yongmei Chen,

Jonathan G. Zaroff,

Stephen Sidney,

Charles E. McCulloch,

William L. Young,

Helen Kim

Publication year - 2011

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000322601

Subject(s) - medicine , arteriovenous malformation , odds ratio , minor allele frequency , single nucleotide polymorphism , intracerebral hemorrhage , angptl4 , confidence interval , intracranial arteriovenous malformations , angiopoietin , gastroenterology , allele , surgery , gene , genotype , vascular endothelial growth factor , genetics , subarachnoid hemorrhage , biology , angiography , cerebral angiography , vegf receptors

Brain arteriovenous malformations (BAVM) are high-flow vascular lesions prone to intracranial hemorrhage (ICH). Abnormal angiogenesis is a key characteristic of BAVM tissue. Angiopoietin-like 4 (ANGPTL4), a secreted glycoprotein, is thought to be involved in angiogenesis and required for proper postnatal blood vessel partitioning. We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH.

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