Agonist Activation of F-Actin-Mediated Eosinophil Shape Change and Mediator Release Is Dependent on Rac2 | Zendy

Paige Lacy | Zendy; Lian Willetts | Zendy; John D. Kim | Zendy; Andrea N. Lo | Zendy; B. Daniël Lam | Zendy; E. MacLean | Zendy; Redwan Moqbel | Zendy; Marc E. Rothenberg | Zendy; Nives Zimmermann | Zendy

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Agonist Activation of F-Actin-Mediated Eosinophil Shape Change and Mediator Release Is Dependent on Rac2

Author(s) -

Paige Lacy,

Lian Willetts,

John D. Kim,

Andrea N. Lo,

B. Daniël Lam,

E. MacLean,

Redwan Moqbel,

Marc E. Rothenberg,

Nives Zimmermann

Publication year - 2011

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000322597

Subject(s) - eosinophil peroxidase , degranulation , superoxide , eosinophil , platelet activating factor , respiratory burst , immunology , chemistry , biology , microbiology and biotechnology , receptor , biochemistry , asthma , enzyme

Tissue recruitment and activation of eosinophils contribute to allergic symptoms by causing airway hyperresponsiveness and inflammation. Shape changes and mediator release in eosinophils may be regulated by mammalian Rho-related guanosine triphosphatases. Of these, Rac2 is essential for F-actin formation as a central process underlying cell motility, exocytosis, and respiratory burst in neutrophils, while the role of Rac2 in eosinophils is unknown.We set out to determine the role of Rac2 in eosinophil mediator release and F-actin-dependent shape change in response to chemotactic stimuli.

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