Open AccessCopy Number Variation of <i>FCGR3B</i> Is Associated with Susceptibility to Idiopathic Pulmonary Fibrosis
Author(s) -
Stylianos Bournazos,
Irini Bournazou,
John T. Murchison,
William Wallace,
Pauline McFarlane,
Nikhil Hirani,
A. John Simpson,
Ian Dransfield,
Simon P. Hart
Publication year - 2010
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000321997
Subject(s) - copy number variation , idiopathic pulmonary fibrosis , medicine , pathogenesis , genetics , biology , gene , lung , genome
Several genes exhibit copy number variation (CNV), including FCGR3B which encodes the IgG receptor FcγRIIIb. Engagement of Fcγ receptors by IgG complexes may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF).
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