Different Expressions and DNA Methylation Patterns of Lysophosphatidic Acid Receptor Genes in Mouse Tumor Cells | Zendy

Kyoko Okabe | Zendy; Mai Hayashi | Zendy; Naoko Wakabayashi | Zendy; Yasuna Yamawaki | Zendy; Miki Teranishi | Zendy; Nobuyuki Fukushima | Zendy; Toshifumi Tsujiuchi | Zendy

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Different Expressions and DNA Methylation Patterns of Lysophosphatidic Acid Receptor Genes in Mouse Tumor Cells

Author(s) -

Kyoko Okabe,

Mai Hayashi,

Naoko Wakabayashi,

Yasuna Yamawaki,

Miki Teranishi,

Nobuyuki Fukushima,

Toshifumi Tsujiuchi

Publication year - 2010

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000321898

Subject(s) - dna methylation , microbiology and biotechnology , biology , methylation , lysophosphatidic acid , receptor , gene , cancer research , gene expression , genetics

Lysophosphatidic acid (LPA) receptors act as several biological effectors through LPA, which is a bioactive phospholipid. Recently, aberrant expressions of LPA receptor genes due to DNA methylation have been detected in several tumor cells. In this study, we measured expression levels and DNA methylation status of LPA receptor genes in mouse tumor cells, LL/2 lung carcinoma, B16F0 melanoma, FM3A mammary carcinoma and L1210 leukemia cells, compared with normal tissues.

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