Statins Reduce Dengue Virus Production via Decreased Virion Assembly | Zendy

Marlén MartínezGutierrez | Zendy; Jaime E. Castellanos | Zendy; Juan Carlos Gallego-Gómez | Zendy

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Statins Reduce Dengue Virus Production via Decreased Virion Assembly

Author(s) -

Marlén MartínezGutierrez,

Jaime E. Castellanos,

Juan Carlos Gallego-Gómez

Publication year - 2011

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000321892

Subject(s) - vero cell , virology , dengue virus , dengue fever , biology , virus , viral replication , viral life cycle , plaque forming unit , viral entry , titer , rna , cell culture , gene , biochemistry , genetics

Most of the effects of statins can be explained by pleiotropic effects independent of their lowering of serum cholesterol; in some cases, these effects have been shown to be a result of the role of statins in the prenylation of cellular proteins, some of which are involved in the life cycle of animal viruses. This study evaluated the potential antiviral activity of lovastatin (LOV) against dengue virus (DENV) infection of epithelial and endothelial cells (VERO cells, epithelial cells derived from African green monkey kidney, and HMEC-1 cells, human dermal microvascular endothelial cells).

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