Quetiapine, Olanzapine and Haloperidol Affect Human Plasma Lipid Peroxidation in vitro | Zendy

Anna DietrichMuszalska | Zendy; Bogdan Kontek | Zendy; Jolanta RabeJabłońska | Zendy

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Quetiapine, Olanzapine and Haloperidol Affect Human Plasma Lipid Peroxidation in vitro

Author(s) -

Anna DietrichMuszalska,

Bogdan Kontek,

Jolanta RabeJabłońska

Publication year - 2011

Publication title -

neuropsychobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.71

H-Index - 83

eISSN - 1423-0224

pISSN - 0302-282X

DOI - 10.1159/000321623

Subject(s) - tbars , chemistry , lipid peroxidation , haloperidol , quetiapine , thiobarbituric acid , pharmacology , oxidative stress , olanzapine , endocrinology , biochemistry , medicine , schizophrenia (object oriented programming) , dopamine , psychiatry

Oxidative injury in schizophrenia may be caused not only by pathophysiological processes but partly also by treatment with antipsychotics. The purpose of the present study was to examine and to compare the effects of quetiapine (QUE), olanzapine (OLA) and haloperidol (HAL), at final concentrations corresponding to doses used for treatment of acute episodes of schizophrenia, on plasma lipid peroxidation in vitro, measured by the level of thiobarbituric acid-reactive substances (TBARS).

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