A Tale of Tailless | Zendy

Hongxing Gui | Zendy; Meiling Li | Zendy; ChihCheng Tsai | Zendy

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A Tale of Tailless

Author(s) -

Hongxing Gui,

Meiling Li,

ChihCheng Tsai

Publication year - 2010

Publication title -

developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 82

eISSN - 1421-9859

pISSN - 0378-5866

DOI - 10.1159/000321585

Subject(s) - biology , demethylase , chromatin , histone , nuclear receptor , forebrain , microbiology and biotechnology , genetics , drosophila melanogaster , transcription factor , neuroscience , gene , central nervous system

Drosophila Tailless(Tll) and its vertebrate homologue Tlx are conserved orphan nuclear receptors specifically expressed in the eye and the forebrain. Tll and Tlx act primarily as transcriptional repressors through their interactions with transcriptional corepressors, Atrophin family proteins, and histone-tail/chromatin-modifying factors such as lysine-specific histone demethylase 1 and histone deacetylases. The functional importance of Tll and Tlx is made apparent by the recent discovery that they are expressed in neural stem cells (NSCs) and are required for self-renewal of these cells in both Drosophila and the mouse. This review provides a snapshot of current knowledge about Tll and Tlx and their transcriptional network, which maintains NSCs in developing and adult animals.

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