Open AccessCaspase-9-Dependent Nuclear Translocation of Cytochrome <i>c</i> in Hypoxic Injury
Author(s) -
JeeYoun Kim,
Yong Jun Kim,
Kum-Ok Seok,
Sun Lee,
JaeHoon Park
Publication year - 2010
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000321568
Subject(s) - cytochrome c , apoptosis , chromosomal translocation , microbiology and biotechnology , western blot , caspase 3 , biology , chemistry , programmed cell death , biochemistry , gene
Hypoxia signals the release of cytochrome c from mitochondria as well as sequential activation of caspase-9 and caspase-3 in the pathway to apoptosis. In this report, we describe novel mechanisms governing the nuclear translocation of cytochrome c during hypoxia-induced apoptosis in neuroepithelioma, SK-N-MC cells.
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