Bile Acids Promote HCV Replication through the EGFR/ERK Pathway in Replicon-Harboring Cells | Zendy

John B. Patton | Zendy; David W. George | Zendy; KyeongOk Chang | Zendy

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Bile Acids Promote HCV Replication through the EGFR/ERK Pathway in Replicon-Harboring Cells

Author(s) -

John B. Patton,

David W. George,

KyeongOk Chang

Publication year - 2011

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000321452

Subject(s) - mapk/erk pathway , replicon , hepatitis c virus , viral replication , biology , interferon , virology , kinase , hela , chemistry , cancer research , microbiology and biotechnology , cell , virus , biochemistry , dna , plasmid

Bile acids promoted the replication of hepatitis C virus (HCV) and compromised the anti-HCV effects of interferon-α (IFN-α) in replicon-harboring cells. To explore a potential mechanism for the observation, we studied the effects of bile acids on the epidermal growth factor receptor (EGFR) and the extracellular signal-regulated kinase (ERK) pathway in association with HCV replication in genotype 1a or 1b replicon-harboring cells.

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