Replicative Activity of Hepatitis B Virus Is Negatively Associated with Methylation of Covalently Closed Circular DNA in Advanced Hepatitis B Virus Infection | Zendy

JinWook Kim | Zendy; Sang Hyub Lee | Zendy; Young Soo Park | Zendy; JinHyeok Hwang | Zendy; SookHyang Jeong | Zendy; Nayoung Kim | Zendy; Dong Hyeon Lee | Zendy

Open Access

Replicative Activity of Hepatitis B Virus Is Negatively Associated with Methylation of Covalently Closed Circular DNA in Advanced Hepatitis B Virus Infection

Author(s) -

JinWook Kim,

Sang Hyub Lee,

Young Soo Park,

JinHyeok Hwang,

SookHyang Jeong,

Nayoung Kim,

Dong Hyeon Lee

Publication year - 2011

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000321450

Subject(s) - cccdna , hepatitis b virus , methylation , dna methylation , cpg site , biology , virology , hepatitis b , microbiology and biotechnology , virus , dna , gene , hbsag , gene expression , genetics

The aim of this study was to examine the methylation status of intrahepatic hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and to elucidate the possible relationship between the cccDNA methylation and viral replicative activity in patients with HBV-related liver cirrhosis (HBV-LC).

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