Clotting Factors and Eicosanoids Protect against Nematode Infections | Zendy

Pavel Hyršl | Zendy; Pavel Dobeš | Zendy; Zhi Wang | Zendy; Thomas Hauling | Zendy; Christine Wilhelmsson | Zendy; Ulrich Theopold | Zendy

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Clotting Factors and Eicosanoids Protect against Nematode Infections

Author(s) -

Pavel Hyršl,

Pavel Dobeš,

Zhi Wang,

Thomas Hauling,

Christine Wilhelmsson,

Ulrich Theopold

Publication year - 2010

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000320634

Subject(s) - nematode , immune system , biology , hemolymph , innate immune system , drosophila melanogaster , microbiology and biotechnology , immunology , blood clotting , biochemistry , gene , medicine , ecology

We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation.

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