Suppression of Par-4 Protects Human Renal Proximal Tubule Cells from Apoptosis Induced by Oxidative Stress | Zendy

Bin Sun | Zendy; Chao Lu | Zendy; Guoping Zhou | Zendy; Xing Changying | Zendy

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Suppression of Par-4 Protects Human Renal Proximal Tubule Cells from Apoptosis Induced by Oxidative Stress

Author(s) -

Bin Sun,

Chao Lu,

Guoping Zhou,

Xing Changying

Publication year - 2010

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000320594

Subject(s) - oxidative stress , apoptosis , gene silencing , pi3k/akt/mtor pathway , protein kinase b , small interfering rna , microbiology and biotechnology , downregulation and upregulation , endocrinology , biology , chemistry , cancer research , medicine , signal transduction , transfection , cell culture , biochemistry , genetics , gene

Oxidative stress is an important inducer of cell apoptosis and plays a key role in the development of renal inflammation. The prostate apoptosis response factor-4 (Par-4) gene was originally identified in prostate cells undergoing apoptosis. Subsequently, Par-4 was found to possess potent pro-apoptotic activity in various cellular systems. However, it remains unclear whether Par-4 is involved in oxidant injury of renal tubular epithelial cells.

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