The Cytoprotective Action of the Potassium Channel Opener BMS-191095 in C2C12 Myoblasts is Related to the Modulation of Calcium Homeostasis | Zendy

Dominika Malińska | Zendy; Bogusz Kulawiak | Zendy; Antoni Wrzosek | Zendy; Wolfram S. Kunz | Zendy; Adam Szewczyk | Zendy

Open Access

The Cytoprotective Action of the Potassium Channel Opener BMS-191095 in C2C12 Myoblasts is Related to the Modulation of Calcium Homeostasis

Author(s) -

Dominika Malińska,

Bogusz Kulawiak,

Antoni Wrzosek,

Wolfram S. Kunz,

Adam Szewczyk

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000320523

Subject(s) - calpain , calcium , chemistry , cytoprotection , myocyte , calcium in biology , microbiology and biotechnology , cytosol , calcium metabolism , ryanodine receptor , pharmacology , oxidative stress , biochemistry , biology , organic chemistry , enzyme

BMS-191095 is an opener of the mitochondrial ATP-regulated potassium channel, which has been shown to provide cytoprotection in models of ischemia-reperfusion induced injury in various tissues. This study aimed at checking the protective action of BMS-191095 under the conditions of oxidative stress or disruption of intracellular calcium homeostasis.

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