Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria | Zendy

Zhijie Xiao | Zendy; Liqun He | Zendy; Minoru Takemoto | Zendy; Hannu Jalanko | Zendy; Guy C.K. Chan | Zendy; Daniel R. Storm | Zendy; Christer Betsholtz | Zendy; Karl Tryggvason | Zendy; Jaakko Patrakka | Zendy

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Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria

Author(s) -

Zhijie Xiao,

Liqun He,

Minoru Takemoto,

Hannu Jalanko,

Guy C.K. Chan,

Daniel R. Storm,

Christer Betsholtz,

Karl Tryggvason,

Jaakko Patrakka

Publication year - 2010

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000320382

Subject(s) - podocyte , medicine , endocrinology , biology , glomerulus , kidney , albuminuria , microbiology and biotechnology , adenylate kinase , proteinuria , receptor

The organization of actin cytoskeleton in podocyte foot processes plays a critical role in the maintenance of the glomerular filtration barrier. The cAMP pathway is an important regulator of the actin network assembly in cells. However, the role of the cAMP pathway in podocytes is not well understood. Type 1 adenylate cyclase (Adcy1), previously thought to be specific for neuronal tissue, is a member of the family of enzymes that catalyses the formation of cAMP. In this study, we characterized the expression and role of Adcy1 in the kidney.

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