Hyperuricemia Attenuates Aortic Nitric Oxide Generation, through Inhibition of Arginine Transport, in Rats | Zendy

Idit F. Schwartz | Zendy; Ayelet Grupper | Zendy; Tamara Chernichovski | Zendy; Oren Hillel | Zendy; Anat Engel | Zendy; Doron Schwartz | Zendy

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Hyperuricemia Attenuates Aortic Nitric Oxide Generation, through Inhibition of Arginine Transport, in Rats

Author(s) -

Idit F. Schwartz,

Ayelet Grupper,

Tamara Chernichovski,

Oren Hillel,

Anat Engel,

Doron Schwartz

Publication year - 2010

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000320356

Subject(s) - benzbromarone , endocrinology , medicine , hyperuricemia , allopurinol , enos , nitric oxide , arginine , arginase , chemistry , nitric oxide synthase , uric acid , biochemistry , amino acid

Hyperuricemia provokes endothelial dysfunction (ECD). Decreased endothelial nitric oxide synthase (eNOS) activity is an important source of ECD. Cationic amino acid transporter-1 (CAT-1) is the specific arginine transporter for eNOS. We hypothesize that hyperuricemia inhibits arginine uptake.

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