A Novel Function of Siglec-9 A391C Polymorphism on T Cell Receptor Signaling | Zendy

Kyung Ah Cheong | Zendy; YoonSeok Chang | Zendy; Joo Young Roh | Zendy; Bum-Jun Kim | Zendy; Myung-Nam Kim | Zendy; Youn Min Park | Zendy; HaiJin Park | Zendy; Nam Doo Kim | Zendy; ChangHoon Lee | Zendy; AiYoung Lee | Zendy

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A Novel Function of Siglec-9 A391C Polymorphism on T Cell Receptor Signaling

Author(s) -

Kyung Ah Cheong,

YoonSeok Chang,

Joo Young Roh,

Bum-Jun Kim,

Myung-Nam Kim,

Youn Min Park,

HaiJin Park,

Nam Doo Kim,

ChangHoon Lee,

AiYoung Lee

Publication year - 2010

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000320225

Subject(s) - siglec , t cell receptor , jurkat cells , biology , sialic acid , receptor , signal transduction , c type lectin , transfection , t cell , microbiology and biotechnology , phosphorylation , immunology , biochemistry , genetics , cell culture , immune system

Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are the best-characterized immunoglobulin-type lectins. There is a growing amount of data linking Siglec and autoimmune diseases. The recently identified Siglec-9 inhibits T cell receptor (TCR)-mediated signaling which has been demonstrated by site-directed mutagenesis. In human Siglec-9, at least 8 nonsynonymous SNPs have been detected without functional studies. This study examined the SNP(s) related to TCR-mediated signaling.

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