Reduced Respiratory Capacity in Muscle Mitochondria of Obese Subjects | Zendy

Linda Bakkman | Zendy; Maria Fernström | Zendy; Peter Loogna | Zendy; Olav Rooyackers | Zendy; Lena Brandt | Zendy; Ylva Trolle Lagerros | Zendy

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Reduced Respiratory Capacity in Muscle Mitochondria of Obese Subjects

Author(s) -

Linda Bakkman,

Maria Fernström,

Peter Loogna,

Olav Rooyackers,

Lena Brandt,

Ylva Trolle Lagerros

Publication year - 2010

Publication title -

obesity facts

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.398

H-Index - 45

eISSN - 1662-4033

pISSN - 1662-4025

DOI - 10.1159/000320167

Subject(s) - medicine , basal metabolic rate , endocrinology , obesity , mitochondrion , respiratory exchange ratio , weight gain , respiration , basal (medicine) , respiratory system , heart rate , diabetes mellitus , anatomy , blood pressure , biology , body weight , biochemistry

The extent of weight gain varies among individuals despite equal calorie overconsumption. Furthermore, weight gain is often less than expected from energy excess. This suggests differences in metabolic efficiency and basal metabolism. Since mitochondrial uncoupling accounts for a substantial portion of the basal metabolic rate, we compared skeletal muscle mitochondrial respiration in obese subjects to normal-weight reference groups with various degrees of physical activity.

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