A Case of Mania following Deep Brain Stimulation for Obsessive Compulsive Disorder | Zendy

Ihtsham Haq | Zendy; Kelly D. Foote | Zendy; Wayne K. Goodman | Zendy; Nicola Ricciuti | Zendy; Herbert E. Ward | Zendy; Atchar Sudhyadhom | Zendy; Charles E. Jacobson | Zendy; Mustafa Siddiqui | Zendy; Michael S. Okun | Zendy

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A Case of Mania following Deep Brain Stimulation for Obsessive Compulsive Disorder

Author(s) -

Ihtsham Haq,

Kelly D. Foote,

Wayne K. Goodman,

Nicola Ricciuti,

Herbert E. Ward,

Atchar Sudhyadhom,

Charles E. Jacobson,

Mustafa Siddiqui,

Michael S. Okun

Publication year - 2010

Publication title -

stereotactic and functional neurosurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.798

H-Index - 63

eISSN - 1423-0372

pISSN - 1011-6125

DOI - 10.1159/000319960

Subject(s) - deep brain stimulation , dystonia , internal capsule , mania , obsessive compulsive , basal ganglia , essential tremor , nucleus accumbens , psychology , movement disorders , psychosurgery , subthalamic nucleus , neuroscience , medicine , physical medicine and rehabilitation , psychiatry , disease , parkinson's disease , bipolar disorder , magnetic resonance imaging , central nervous system , cognition , white matter , radiology

Deep brain stimulation (DBS) of the basal ganglia is an effective treatment for select movement disorders, including Parkinson's disease, essential tremor and dystonia. Based on these successes, DBS has been explored as an experimental treatment for medication-resistant neuropsychiatric disease. During a multiyear experience employing DBS to treat patients for obsessive compulsive disorder (OCD) we encountered several unanticipated stimulation-induced psychiatric side effects. We present a case of a young woman treated for OCD with DBS of the anterior limb of the internal capsule and nucleus accumbens region, who subsequently manifested a manic episode. We aim to discuss the case details, treatment and potential neuroanatomical underpinnings of this response.

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