Identification of a New Antigen Epitope in the Nuclear Localization Signal Region of Porcine Circovirus Type 2 Capsid Protein
Author(s) -
Longjun Guo,
Yuehua Lu,
Liping Huang,
Yanwu Wei,
Changming Liu
Publication year - 2010
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000319838
Subject(s) - epitope , porcine circovirus , capsid , microbiology and biotechnology , circovirus , monoclonal antibody , recombinant dna , linear epitope , antigen , biology , fusion protein , epitope mapping , virology , western blot , conformational epitope , nls , antibody , nuclear localization sequence , virus , biochemistry , gene , genetics
Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic syndrome in pigs. The capsid (Cap) protein encoded by ORF2 is the main structural protein involved in the host immune protective response to PCV2. It is therefore important to map the antigenic epitopes of the PCV2 Cap protein.
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