Vaccination with Different M2e Epitope Densities Confers Partial Protection against H5N1 Influenza A Virus Challenge in Chickens | Zendy

Xintao Zhang | Zendy; Ming Liu | Zendy; Chunguo Liu | Zendy; Du JinLing | Zendy; Weilin Shi | Zendy; Encheng Sun | Zendy; Hongtao Li | Zendy; Jianhui Li | Zendy; Yun Zhang | Zendy

Open Access

Vaccination with Different M2e Epitope Densities Confers Partial Protection against H5N1 Influenza A Virus Challenge in Chickens

Author(s) -

Xintao Zhang,

Ming Liu,

Chunguo Liu,

Du JinLing,

Weilin Shi,

Encheng Sun,

Hongtao Li,

Jianhui Li,

Yun Zhang

Publication year - 2011

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000319440

Subject(s) - virology , immunogenicity , epitope , influenza a virus subtype h5n1 , biology , fusion protein , virus , recombinant dna , vaccination , influenza a virus , western blot , immune system , inactivated vaccine , antibody , gene , immunology , genetics

Currently, research is focused on universal influenza vaccines based on various ectodomains of the influenza matrix protein 2 (M2e). Such vaccines are tested mostly using mouse-adapted influenza viruses and in mouse or ferret models. The aim of this study was to investigate in a chicken model the protective efficacy of vaccines based on avian-type M2e at different epitope densities.

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