Arterial Calcification Is Driven by RAGE in Enpp1–/– Mice | Zendy

Denise L. Cecil | Zendy; Robert Terkeltaub | Zendy

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Arterial Calcification Is Driven by RAGE in <i>Enpp1</i>–/– Mice

Author(s) -

Denise L. Cecil,

Robert Terkeltaub

Publication year - 2010

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000318805

Subject(s) - rage (emotion) , ectopic calcification , calcification , chemistry , endocrinology , medicine , knockout mouse , cartilage , glycation , receptor , biology , anatomy , neuroscience

Ectopic osteochondral differentiation, driven by ENPP1-catalyzed generation of the chondrogenesis and calcification inhibitor inorganic pyrophosphate (PP(i)), promotes generalized arterial calcification of infancy. The multiligand receptor for advanced glycation end-products (RAGE), which promotes atherosclerosis and diabetic cardiovascular and renal complications, also mediates chondrocyte differentiation in response to RAGE ligand calgranulins such as S100A11. Here, we tested RAGE involvement in ENPP1 deficiency-associated arterial calcification.

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