Marfan Syndrome Decreases Ca2+ Wave Frequency and Vasoconstriction in Murine Mesenteric Resistance Arteries without Changing Underlying Mechanisms | Zendy

Harley T. Syyong | Zendy; A.W. Chung | Zendy; C. van Breemen | Zendy

Open Access

Marfan Syndrome Decreases Ca<sup>2+</sup> Wave Frequency and Vasoconstriction in Murine Mesenteric Resistance Arteries without Changing Underlying Mechanisms

Author(s) -

Harley T. Syyong,

A.W. Chung,

C. van Breemen

Publication year - 2010

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000318804

Subject(s) - medicine , endocrinology , cyclopiazonic acid , contraction (grammar) , chemistry , mesenteric arteries , biology , calcium , artery

Vascular smooth muscle in Marfan syndrome, a connective tissue disorder caused by mutations in FBN1 encoding fibrillin-1, is associated with decreased tonic contraction. As Ca(2+) waves are tightly associated with vasoconstriction, we hypothesized decreased tonic contraction in Marfan syndrome is due to aberrant Ca(2+) wave signaling.

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