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Tissue Factor Is Induced by Resistin in Human Coronary Artery Endothelial Cells by the NF-ĸB-Dependent Pathway
Author(s) -
Paolo Calabró,
Plinio Cirillo,
Giuseppe Limongelli,
Valeria Maddaloni,
Lucia Riegler,
Rosalinda Palmieri,
Giuseppe Pacileo,
Salvatore De Rosa,
Mario Pacileo,
Raffaele De Palma,
Paolo Golino,
Raffaele Calabrò
Publication year - 2010
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000318775
Subject(s) - resistin , tissue factor , medicine , endocrinology , downregulation and upregulation , inflammation , nfkb1 , adipokine , endothelium , endothelial dysfunction , biology , superoxide dismutase , transcription factor , chemistry , oxidative stress , biochemistry , leptin , gene , coagulation , obesity
Atherosclerosis is characterized by endothelial inflammation and dysfunction. Adipose tissue has increasingly been recognized as an active endocrine organ secreting so-called adipokines. Among these, resistin--recently described, but not yet extensively studied--has been defined as a novel inflammatory marker in atherosclerosis. The pathophysiology underlying this interplay, however, remains to be fully characterized. The aim of the study is to determine whether resistin might affect prothrombotic characteristics of human coronary artery endothelial cells (HCAECs).

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