Open AccessFlagellin Induces the Expression of Thymic Stromal Lymphopoietin in Human Keratinocytes via Toll-Like Receptor 5
Author(s) -
Tuấn Anh Lê,
Toshiro Takai,
Tuan A. Vu,
Hirokazu Kinoshita,
Xue Chen,
Shigaku Ikeda,
Hideoki Ogawa,
Ko Okumura
Publication year - 2010
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000318679
Subject(s) - thymic stromal lymphopoietin , flagellin , tlr5 , toll like receptor , immunology , gene knockdown , biology , cytokine , downregulation and upregulation , keratinocyte , proinflammatory cytokine , allergic inflammation , inflammation , receptor , microbiology and biotechnology , immune system , innate immune system , cell culture , gene , biochemistry , genetics
Thymic stromal lymphopoietin (TSLP), highly expressed by keratinocytes in skin lesions of atopic dermatitis patients and bronchial epithelial cells in asthma, plays a key role in allergic diseases. Information on triggers for the release of TSLP in keratinocytes is still limited. Keratinocytes express Toll-like receptor (TLR) 5, the ligand for which is flagellin, the major structural protein of the flagella of Gram-negative bacteria. IL-4, IL-13 and TNF-α (Th2/TNF) are associated with allergic diseases. TGF-α, one of the ligands for the epidermal growth factor receptor, is overexpressed in keratinocytes in atopic dermatitis. We investigated the induction of TSLP expression in keratinocytes stimulated with flagellin and its modulation by the Th2/TNF cytokines and TGF-α.
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